Projects & Grants
The HRS4R human resources management strategy for the scientific sector was funded through the project „HR Excellence in Research na Ostravské univerzitě“, Reg. No.: CZ.02.2.69/0.0/0.0/16_028/0006225.
| Engineering the Immune Synapse: A New Framework for CAR T-Cell Design | |
|---|---|
| Project Id | |
| Main solver | doc. RNDr. Michal Šimíček, PhD. |
| Period | 7/2026 - 10/2028 |
| Provider | Klinika hematoonkologie, Moravskoslezský kraj |
| State | solved |
| Anotation | Dr. Sourabh will work in the Blood Cancer Research Group, Faculty of Medicine, University of Ostrava, where his activities will focus on the molecular mechanisms of T-cell activation and the development of next-generation immunotherapies for hematological malignancies. The project will investigate the composition, signaling dynamics, and functional properties of the chimeric antigen receptor (CAR)-based immune synapse in comparison to the physiological TCR-mediated synapse. Using advanced protein engineering, CRISPR/Cas9 genome editing in primary human T cells, and high-dimensional imaging and proteomic approaches, the study aims to identify key regulatory nodes that determine CAR T-cell efficacy, persistence, and specificity. A particular emphasis will be placed on designing and validating novel synthetic receptors and immune synapse-associated modules with improved control of T-cell activation. The translational component of the project will focus on preclinical validation of optimized CAR T-cell strategies, with the goal of accelerating their implementation into clinically relevant settings for the treatment of blood cancers. |
| Total Costs | 4 044 656 CZK |
