Projects & Grants
| Eukaryotic diversity and adaptation: an integrative multi-omics approach to molecular mechanisms | |
|---|---|
| Project Id | SGS06/PŘF/2026 |
| Main solver | Mgr. Karolína Skýpalová |
| Period | 1/2026 - 12/2026 |
| Provider | Specifický VŠ výzkum |
| State | solved |
| Anotation | This project focuses on a comprehensive investigation of evolutionary processes, genome architecture and viral interactions across major eukaryotic lineages through the integration of advanced bioinformatic, genomic, transcriptomic and proteomic methodologies. Its overarching aim is to establish a unified analytical framework for elucidating the molecular mechanisms that shape eukaryotic diversity and determine cellular function. The research encompasses several complementary themes: annotation and phylogenetic analysis of the Ras gene superfamily and additional cilium-associated proteins across deeply divergent taxa (1); detailed examination of mitochondrial genetic code evolution in opisthokonts with emphasis on the molecular determinants and functional implications of codon reassignment (2); development of an automated computational pipeline for the detection of selected eukaryotic dsDNA viruses, their phylogenomic inference and systematic genome annotation (3); characterization of intron diversity and spliceosomal adaptations within the Euglenozoa (4); multi-omic analyses of the biology of Trypanosomatidae including the mechanisms of Leishmania RNA virus maintenance and subcellular protein localization using LOPIT (5); and comparative transcriptomic profiling of circulating tumor cells and bone-marrow plasma cells in multiple myeloma patients to identify molecular factors enabling tumor cell egression from the bone-marrow niche (6). Although primarily fundamental in nature, the project is expected to generate data and methodological tools with broader relevance for future applications in viral diagnostics, clinical genomics and biomedical research. Outcomes will be disseminated through peer-reviewed publications and presentations at international scientific conferences. Due to the involvement of a student from abroad the individual thematic parts of the project are processed internally and presented mainly in English. |
| Total Costs | 829 000 CZK |
