Projects & Grants
| Perineural Invasion in Oral Squamous Cell Carcinoma: Towards Novel Prognostic Markers and Therapeutic Strategies | |
|---|---|
| Project Id | NW26-08-00024 |
| Main solver | RNDr. Matouš Hrdinka, Ph.D. |
| Period | 1/2026 - 12/2029 |
| Provider | Agentura zdravotnického výzkumu ČR |
| State | solved |
| Anotation | Oral squamous cell carcinoma (OSCC) represents the most common malignancy of the oral cavity, often diagnosed in advanced stages due to perineural invasion (PNI), a significant prognostic factor linked to poor survival outcomes. This project investigates the molecular mechanisms underpinning PNI in OSCC, with a focus on the role of BRCA1 and BRCA2 gene mutations. Our preliminary data have identified distinct mutational profiles correlated with PNI presence, suggesting potential as novel biomarkers for OSCC aggressiveness. We aim to refine diagnostic and prognostic models by integrating these molecular findings with clinical and histopathological features to predict disease progression and recurrence. The project will also explore therapeutic interventions targeting BRCA mutations using PARP inhibitors, potentially offering new strategies for managing OSCC and targeting PNI. This comprehensive approach promises to advance our understanding of OSCC pathophysiology and to develop more effective diagnostic tools and therapeutic options, thereby enhancing patient outcomes in OSCC treatment. |
| Total Costs | 14 035 000 CZK |
