Projects & Grants
| Effect of radiotherapy on changes of mucosa vascularization in head and neck tumour | |
|---|---|
| Project Id | SGS04_2021 |
| Main solver | MUDr. Peter Kántor |
| Period | 1/2021 - 12/2021 |
| Provider | Specifický VŠ výzkum |
| State | finished |
| Anotation | Radiotherapy is one of the treatment modalities for head and neck cancer. It can be used as monotherapy or in combination with surgical treatment. When it comes to primary surgical treatment, its invasiveness is often problematic. In the case of insufficient tumor removal, a recurrence may arise. On the other hand, excessive resection can have severe anatomical and functional consequences on the patients life (hoarseness of voice, loss of voice, swallowing difficulties, etc.). Nevertheless, oncology treatment in the form of chemotherapy or radiation therapy is associated with a lower success rate. Presently, advanced endoscopic methods such as NBI or IMAGE1S are used for subsequent monitoring of the treatment?s effects on mucosal tumor vascularization. These methods allow for early identification of recovering patients with suspected recurrence. If patient was treated with radiotherapy the mucosal vascularization changes in response to it. Thus, the differentiation between vascular changes caused by the tumor and the radiotherapy becomes difficult. These morphological alterations have not yet been sufficiently reported in literature. In this study, these advanced endoscopic techniques are used to thoroughly describe the vascularization changes and their dependency on the dosage and the time elapsed from the radiotherapy. |
