Projects & Grants

Internal Grant Competition DGC
START-UP grant

Aberrant plasma cells clonal diversification in immunoglobulin light chain amyloidosis
Project Id15-29667A
Main solverprof. MUDr. Roman Hájek, CSc.
Period5/2015 - 12/2019
ProviderIGA MZd
AnotationImmunoglobulin light chain amyloidosis (ALA) is a haematological disorder and may coexist with other plasma cell (PC) dyscrasias. It hasbeen reported that 10% of ALA patients may have multiple myeloma (MM) at the same time. Nevertheless, it is still unclear if such clinicalmanifestation is defined by aberrant PC clones architecture or subsequent clone evolution. Due to the development in next generationsequencing (NGS) technology, it is possible now to model clonal differentiation during tumour progression. We suspect that, presence ofdifferent ALA and MM clones can be explained as a result of clone diversification during disease progression (branched evolution).Alternatively, severe genomic changes in aberrant PC can cause forming of new unique clone responsible for mentioned clinical manifestation(linear evolution). Learning outcomes of the offered project would mean certainly progress in the terms of diagnosis and subsequent treatmentof ALA patients.