UO

Roman Hájek

Vice-Rector for Strategy and Development

Roman Hájek

Academic degree, name, surname:prof. MUDr. Roman Hájek, CSc.
Room, floor, building: R 204, Building R
Position:Vice-Rector
Research interests and teaching:
Department (Faculty): Department of Clinic Subjects (Faculty of Medicine)
University Offices
Phone number, mobile: +420 553 46 1013
+420 597 372 091
E-mail:
Personal website:

Work experience

2012 – presentHead of Department of Clinical Hematooncology; University Hospital Ostrava, Czech Republic
2015 – presentVice-Rector for Strategy and Development; University of Ostrava, Czech Republic
2011 – 2015Project manager of Babak Myeloma Group; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2012 – 2014Vice-dean for Science and Research; Faculty of Medicine, Ostrava University, Czech Republic
2010 – 2011Director of Babak Research Institute; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
2007 – 2012Vice-Director for Education and Research; University Hospital Brno, Brno, Czech Republic
1999 – presentHead of Laboratory of Experimental Hematology and Cell Immunotherapy; University Hospital Brno, Brno, Czech Republic
1989 – 2012Physician; Department of Internal Medicine Hematooncology, University Hospital Brno, Brno, Czech Republic

Education and training

2006Prof. - Masaryk University, Brno, Czech Republic; Field of Study: Clinical Oncology
2001Assoc Prof. - Department of Internal Medicine and Hemato-oncology, Masaryk University Hospital Brno, Czech Republic; Field of Study: Internal Medicine
1995Ph.D. - Department of Internal Medicine and Hemato-oncology, Masaryk University Hospital Brno, Czech Republic; Field of Study: Hematooncology
1988M.D. - Masaryk University, Brno, Czech Republic; Field of Study: General Medicine

Research and professional experience

1995Georgetown University Medical Center, WA, D. C., USA
1996ESO course Molecular Biology for Clinicians; Cambridge, United Kingdom
1997Arkansas Myeloma Research Center, USA
1998Arkansas Myeloma Research Center, USA
2001Royal Prince Alfred Hospital of Hematooncology - Sydney, Austrálie

Memberships

Since 1994Czech Society of Hematology and Oncology (Head of Myeloma Committee since 2006)
Since 1996Czech Myeloma Group, Chairman
Since 2001Czech Myeloma Group Foundation, Chairman
Since 2005Medical Advisory Board of Myeloma Euronet
Since 2007Scientific Advisory Board of the International Myeloma Foundation
Since 2007European Myeloma Network (Member of the Board since 2019)
Since 2008International Myeloma Working Group
Since 2008American Society of Hematology
Since 2009European Hematology Association
Since 2012International Myeloma Society

Honours and awards

IMF Brian D. Novis research grant funded through the Black Swan Research Initiative


A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors
Year: 2020, CANCERS
journal article

A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma
Roman Hájek, Luděk Pour, Edyta Dawbovská, Muhit Ozcan, Jesus Martin Sanchez, Ivan Špička ... other authors
Year: 2020, EUROPEAN JOURNAL OF HAEMATOLOGY
journal article

Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study
M. Cavo, F. Gay, M. Beksac, L. Pantani, M.T. Petrucci, A.M. Dimopoulos, L. Dozza, B. van der Holt, S. Zweegman, S. Oliva, Roman Hájek ... other authors
Year: 2020, LANCET HAEMATOLOGY
journal article

Bortezomib Retreatment Is Effective in Relapsed Multiple Myeloma Patients - Real-Life Clinical Practice Data
M. Stork, S. Ševčíková, L. Brožová, I. Špička, V. Maisnar, J. Minařík, A. Jungová, E. Gregora, R. Velichová, Roman Hájek, Tomáš Jelínek, L. Pour ... other authors
Year: 2020, Neoplasma
journal article

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients
David Vrabel, Lenka Sedlaříková, Lenka Besse, Lucie Říhová, Renata Bezděková, Martina Almasi, Veronika Kubaczková, Lucie Brožová, Jiří Jarkovský, Hana Plonková, Tomáš Jelínek, Viera Sandecká, Martin Stork, Luděk Pour, Sabina Ševčíková, Roman Hájek ... other authors
Year: 2020, European Journal of Haematology
journal article

First-line therapy with either bortezomibmelphalan- prednisone or lenalidomidedexamethasone followed by lenalidomide for transplant-ineligible multiple myeloma patients: a pooled analysis of two randomized trials
A. Larocca, R. Mina, M. Offidani, Roman Hájek
Year: 2020, Haematologica
journal article

Identifying and treating candidates for checkpoint inhibitor therapies in multiple myeloma and lymphoma
Katarina Hradská, Michal Kaščák, Roman Hájek, Tomáš Jelínek
Year: 2020, Expert Review of Hematology
journal article

Intercellular Mitochondrial Transfer in the Tumor Microenvironment
Hana Šahinbegović, Tomáš Jelínek, Matouš Hrdinka, Julio Rodriguez Bago, Marcello Turi, Tereza Ševčíková, Amina Kurtovic-Kotaric, Roman Hájek, Michal Šimíček ... other authors
Year: 2020, Cancers
journal article

Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN)
E. Terpos, M. Engelhardt, G. Cook, Roman Hájek
Year: 2020, LEUKEMIA
journal article

Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data
M. Campioni, I. Agirrezabel, Roman Hájek, J. Minařík, L. Pour, I. Špička, S. Gonzalez-McQuire, P. Jandová, V. Maisnar ... other authors
Year: 2020, European Journal of Health Economics
journal article

Monoclonal antibodies in the treatment of AL amyloidosis: co-targetting the plasma cell clone and amyloid deposits
Tereza Popková, Roman Hájek, Tomáš Jelínek
Year: 2020, BRITISH JOURNAL OF HAEMATOLOGY
journal article

Once- versus twice-weekly carfilzomib in relapsed and refractory multiple myeloma by select patient characteristics: phase 3 ARROW study subgroup analysis
A. Meletios, R. Niesvizky, K. Weisel, Roman Hájek
Year: 2020, Blood Cancer Journal
journal article

Outcome of paraosseous extra-medullary disease in newly diagnosed multiple myeloma patients treated with new drugs
M. Vittorio, G. Francesca, S. Spada, Roman Hájek
Year: 2020, HAEMATOLOGICA
journal article

Real-world effectiveness and safety of ixazomib-lenalidomide-dexamethasone in relapsed/refractory multiple myeloma
E. Terpos, K. Ramasamy, N. Maouche, J. Minařík, I. Ntanasis-Stathopoulos, E. Katodritou, W. M. Jenner, H. Plonková, M. Kotsoupolou, J. Kothari, Tomáš Jelínek, A. M. Dimopoulos, A. Zomas, Roman Hájek ... other authors
Year: 2020, ANNALS OF HEMATOLOGY
journal article

Real-world outcomes and factors impacting treatment choice in relapsed and/or refractory multiple myeloma (RRMM): a comparison of VRd, KRd, and IRd
A. Chari, P.G. Richardson, D. Romanus, Roman Hájek
Year: 2020, Expert Review of Hematology
journal article

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination
J.J. Garces, Michal Šimíček, M. Vicari, L. Brožová, L. Burgos, R. Bezděková, A. Diego, M.J. Calasanz, Kateřina Growková, Alexander Vdovin, Tomáš Jelínek, Roman Hájek ... other authors
Year: 2020, LEUKEMIA
journal article

Venetoclax plus bortezomib and dexamethasone in heavily pretreated end-stage myeloma patients without t(11;14): A real-world cohort
Tomáš Jelínek, Tereza Popková, Juraj Ďuraš, Jana Fečková Mihályová, Kateřina Benková, Lucie Černá, Zdeněk Kořístek, Michal Šimíček, Roman Hájek ... other authors
Year: 2020, HEMATOLOGICAL ONCOLOGY
journal article

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial
Roman Hájek
Year: 2019, LANCET
journal article

Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma
T. Tacon, JH Lee, P. Morau, R. Niesvizky, M. Dimopoulos, Roman Hájek, L. Pour, A. Jurczyszyn, L. Qiu, Z. Klippel, A. Zahlten-Kumeli, M. Osman, B. Paiva, J. San-Miguel ... other authors
Year: 2019, BLOOD
journal article

Comprehensive care improves the prognosis of women with severe HELLP syndrome and postpartal thrombotic microangiopathic syndrome
Jaromír Gumulec, Ondřej Šimetka, Erika Doležálková, Zdeněk Kořístek, Milan Navrátil, Lucie Broskevičová, Lucie Recová, Kateřina Andelová, I. Lochman, J. Martínek, Roman Hájek, David Kaspřák, M. Tvrdá, Kateřina Notari, Lucie Gregorová, Petra Kovářová ... other authors
Year: 2019
abstract in proceedings

Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma
Roman Hájek, Tomáš Jelínek, Lucie Adamusová, Tereza Popková, Jana Smejkalová, Michal Šimíček, Dana Salounová, Michal Kaščák, Jana Mihalyová, Hana Plonková, Juraj Ďuraš, Milan Navrátil, Zdeněk Kořístek ... other authors
Year: 2019, BONE MARROW TRANSPL
journal article

Development of an Initial Conceptual Model of Multiple Myeloma to Support Clinical and Health Economics Decision Making
Sebastian Gonzalez-McQuire, MA. Dimopoulos, Katja Weisel, Roman Hájek, M. Campioni, C. Bennison, W. Xu, K. Pantiri, M. Hensen, E. Terpoz, S. Knop ... other authors
Year: 2019, MDM Policy & Practice
journal article

Extramedullary disease in multiple myeloma - controversies and future directions
Roman Hájek, Sabina Ševčíková, Jiří Minařík, Martin Stork, Tomáš Jelínek, Luděk Pour ... other authors
Year: 2019, BLOOD REV
journal article

Health-related quality of life in the ENDEAVOR study: carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed/refractory multiple myeloma
Roman Hájek, Kim Cocks, Jaqueline Buchanan, Katja Weisel, Shibao Feng, Martin Keiser, Maria-Victoria Mateos, Meletios A. Dimopoulos, Philippe Morea, Heinz Ludwig ... other authors
Year: 2019, BLOOD CANCER JOURNAL
journal article

Chimeric antigen receptor T-cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network
Philippe Moreau, Pieter Sonneveld, Mario Boccadoro, Gordon Cook, Ma Victoria Mateos, Hareth Nahi, Hartmut Goldschmidt, Meletios A. Dimopoulos, Paulo Lucio, Joan Blade, Michel Delforge, Roman Hájek, Heinz Ludwig, Thierry Facon, Jesus F. San Miguel, Hermann Einsele ... other authors
Year: 2019, HAEMATOLOGICA
journal article

Lenalidomide and dexamethasone in treatment of patients with relapsed and refractory multiple myeloma - analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies
Roman Hájek, V. Maisnar, Z. Stefanikova, I. Spicka, L. Pour, J. Minařík, M. Flochová, J. Radocha, E. Gregora, N. Stecová, Tomáš Jelínek, A. Jungová, E. Kralíková, L. Brožová ... other authors
Year: 2019, NEOPLASMA
journal article

Lenalidomide Maintenance with or without Prednisone in Newly Diagnosed Myeloma Patients: A Pooled Analysis
F. Bonello, S. Pulini, S. Ballanti, M. Gentile, S. Spada, O. Annibali, P. Omede, S. Ronconi, C. Cangialosi, L. Podda, Roman Hájek ... other authors
Year: 2019, CANCERS
journal article

Levels of CEACAM6 in Peripheral Blood Are Elevated in Patients with Plasma Cell Disorders: A Potential New Diagnostic Marker and a New Therapeutic Target?
N. Steiner, D. Nachbaur, B. Borjan, S. Ševčíková, G. Goebel, E. Gunsilius, Roman Hájek ... other authors
Year: 2019, DISEASE MARKERS
journal article

Multiple myeloma in patients up to 30 years of age: a multicenter retrospective study of 52 cases
Roman Hájek, A. Jurczyszyn, J. Davila, K.M. Kortüm, D.S. Jayabalan, R. Vij, M. Fiala, V. Milunovic, C.S. Chim, K. Wiśniewska-Piaty, A. Waszczuk-Gajda, E. Crusoe, P. Robak, M. Raźny, D. Zawirska, M. Bittrich, H. Nahi, H. Liu, J.J. Castillo, D.H. Vesole ... other authors
Year: 2019, Leukemia and Lymphoma
journal article

PREDICTIVE VALUE OF PRIMA?PROGNOSTIC INDEX (PRIMA?PI) IN FIRST RELAPSE OF FOLLICULAR LYMPHOMA
Juraj Ďuraš, V. Procházka, D. Belada, A. Janíková, H. Móciková, Roman Hájek, M. Trněný ... other authors
Year: 2019
abstract in proceedings

Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients
Roman Hájek, A. Jurczyszyn, J.J. Castillo, I. Avivi, J. Czepiel, J. Davila, R. Vij, M.A. Fiala, A. Gozzetti, N. Grzaśko, V. Milunovic, I. Hus, K. Madry, A. Waszcuk-Gajda, L. Usnarska-Zubkiewicz, J. Debski, E. Atilla, M. Beksac, G. Mele, W. Sawicki, D. Jaybalan, G. Charliński, A.G. Szabo, M. Delforge, A. Kopacz, D. Fantl, A. Waage, E. Crusoe, V. Hungria, P. Richardson, J. Laubach, T. Guerrero-Garcia, J. Liu, D.H. Vesole ... other authors
Year: 2019, Leukemia & Lymphoma
journal article

Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients
Artur Jurczyszyn, Jorge J. Castillo, Irit Avivi, Jacek Czepiel, Julio Davila, Ravi Vij, Mark A. Fiala, Alessandro Gozzetti, Norbert Grzasko, Roman Hájek ... other authors
Year: 2019, LEUKEMIA LYMPHOMA
journal article

Simplified novel prognostic score for real-life older adults with multiple myelomaregistry-based analysis
Roman Hájek, J. Radocha, L. Brožová, L. Pour, I. Spicka, J. Minařík, E. Gregorová, A. Jungová, Tomáš Jelínek, A. Heindorfer, M. Sykora, V. Maisnar ... other authors
Year: 2019, ANN HEMATOL
journal article

Single agent daratumumab in advanced multiple myeloma possesses significant efficacy even in an unselected 'real-world' population
Roman Hájek, Jiří Minařík, Luděk Pour, Vladimír Maisnar, Ivan Špička, Alexandra Jungová, Tomáš Jelínek, Lucie Brožová, Petra Krhovská, Vlastimil Scudla ... other authors
Year: 2019, BIOMEDICAL PAPERS-OLOMOUC
journal article

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t(11;14)
Roman Hájek, Tomáš Jelínek, Jana Fečková Mihályová, Juraj Ďuraš, Tereza Popková, Kateřina Benková, Hana Plonková, Jana Zuchnická, Lucie Broskevičová, Lucie Huvarová, Lucie Černá, Kateřina Growková, Michal Šimíček, Martin Havel, Jaromír Gumulec, Zdeněk Kořístek, Bruno Paiva, Petra Richterová, Milan Navrátil, Michal Kascák ... other authors
Year: 2019, AMERICAN JOURNAL OF HEMATOLOGY
journal article

Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia
Zdeněk Král, Jozef Michalka, Heidi Mociková, Jana Marková, Alice Sýkorová, David Belada, Alexandra Jungová, Samuel Vokurka, Marie Lukášová, Vít Procházka, Juraj Ďuraš, Roman Hájek, Ladislav Dušek, Luhos Drgona, Miriam Ladická, Veronika Ballová, Andrei Vranovský ... other authors
Year: 2019, JOURNAL OF CANCER
journal article

A phase I/II dose-escalation study investigating all-oral ixazomib-melphalanprednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma
Jesús F. San-Miguel, Maria-Asunción Echeveste Gutierrez, Ivan Špicka, María-Victoria Mateos, Kevin Song, Michael D. Craig, Joan Bladé, Roman Hájek, Christine Chen, Alessandra Di Bacco, Jose Estevam, Neeraj Gupta, Catriona Byrne, Vickie Lu, Helgi van de Velde, Sagar Lonial ... other authors
Year: 2018, HAEMATOL-HEMATOL J
journal article

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients
Tomáš Jelínek, Roman Hájek, V. Maisnar, L. Pour, I. Špička, J. Minařík, E. Gregora, P. Kessler, M. Sýkora, H. Fraňková, D. Adamová, M. Wróbel, P. Mikula, J. Jarkovský, J. Diels, X. Gatopoulou, H Besson, L. Brožová, T. lto, Š. Veselá ... other authors
Year: 2018, Current Medical Research and Opinion
journal article

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials
Roman Hájek, AK Stewart, SD Russell, P. Moreau, J. Herrmann, J. Banchs, J. Groarke, AR Lyon, GN Batty, S. Ro, M. Huang, KS Iskander, D. Lenihan, A. Chari ... other authors
Year: 2018, Blood Advances
journal article

Automatizované promývání transplantátů krvetvorných buněk pro autologní použití
Lucie Adamusová, Zdeněk Kořístek, Jana Smejkalová, Milan Navrátil, Lukáš Grebeníček, Ivana Tvrdá, Magda Michalíková, Roman Hájek ... other authors
Year: 2018, Transfuze a hematologie dnes
journal article

CD38 cílená léčba u mnohočetného myelomu
Tomáš Jelínek, Jana Fečková Mihályová, Roman Hájek
Year: 2018, Vnitřní lékařství
journal article

Clinical predictors of long-term survival in newly diagnosed transplant eligible multiple myeloma - an IMWG Research Project
A. Hoering, M. Cavo, SZ Usmani, J. San Miguel, H. Goldschimdt, I. Turesson, JJ Lahuerta, M. Attal, B. Barlogie, JH Lee, S. Kumar, S. Lenhoff, G. Morgan, SV Rajkumar, BGM Durie, P. Moreau, Roman Hájek ... other authors
Year: 2018, Blood Cancer Journal
journal article

European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias
Roman Hájek, M. Gavriatopoulou, P. Musto, J. Caers, G. Merlini, E. Kastritis, N. van de Donk, F. Gay, U. Hegenbart, S. Zweegman, B. Bruno, C. Straka, MA. Dimopoulos, H. Einsele, M. Boccadoro, P. Sonneveld, M. Engelhardt, E. Terpos ... other authors
Year: 2018, Leukemia
journal article

From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives
F. Gay, M. Engelhardt, E. Terpos, R. Wasch, L. Giaccone, H.W. Auner, J. Caers, M. Gramatzki, N. van de Donk, S. Oliva, E. Zamagni, L. Garderet, Ch. Straka, Roman Hájek, H. Ludwig, H. Einsele, M. Dimopoulos, M. Boccadoro, N. Kroger, M. Cavo, H. Goldschmidt, B. Bruno, P. Sonneveld ... other authors
Year: 2018, HAEMATOLOGICA
journal article

Maintenance Treatment and Survival in Patients With Myeloma A Systematic Review and Network Meta-analysis
F. Gay, G. Jackson, L. Rosinol, S.A. Holstein, P. Moreau, S. Spada, F. Davies, J.J. Lahuerta, X. Leleu, S. Bringhen, A. Evangelista, C. Hulin, U. Panzani, D.A. Cairns, F. Di Raimondo, M. Macro, A.M. Liberati, C. Pawlyn, M. Offidani, A. Spencer, Roman Hájek, E. Terpos, G.J. Morgan, J. Blade, P. Sonneveld, J. San-Miguel, P.L. McCarthy, H. Ludwig, M. Boccadoro, MV Mateos, M. Attal ... other authors
Year: 2018, Jama Oncology
journal article

Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing
Zuzana Kufová, Tereza Ševčíková, J. Januska, P. Vojta, A. Boday, P. Vanickova, Jana Filipová, Kateřina Growková, Tomáš Jelínek, M. Hajduch, Roman Hájek ... other authors
Year: 2018, JOURNAL OF CLINICAL PATHOLOGY
journal article

Obinutuzumab v první linii léčby chronické lymfocytární leukemie - zkušenosti z klinické praxe
J. Zuchnicka, J. Feckova Mihalyova, L. Istvanikova, Roman Hájek
Year: 2018, Remedia, Od teorie k praxi
journal article

Plasma levels of the angiogenic cytokine Endocan are elevated in patients with multiple myeloma
Roman Hájek
Year: 2018
abstract in proceedings

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network
Roman Hájek, H. Ludwig, M. Delforge, T. Facon, H. Einsele, F. Gay, P. Moreau, H. Avet-Loiseau, M. Boccadoro, M. Mohty, M. Cavo, MA Dimopoulos, JF San-Miguel, E. Terpos, S. Zweegman, L. Garderet, MV Mateos, G. Cook, X. Leleu, H. Goldschmidt, G. Jackson, M. Kaiser, K. Weisel, NWCJ van de Donk, A. Waage, M. Beksac, UH Mellqvist, M. Engelhardt, J. Caers, C. Driessen, J. Blade, P. Sonneveld ... other authors
Year: 2018, LEUKEMIA
journal article

Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients
A. Jurczyszyn, J. Radocha, J. Davila, M.A. Fiala, A. Gozzetti, N. Grzasko, P. Robak, I. Hus, A. Waszczuk-Gajda, R. Guzicka-Kazimierczak, E. Atilla, G. Mele, W. Sawicki, D.S. Jayabalan, G. Charlinski, A.G. Szabo, Roman Hájek ... other authors
Year: 2018, BRITISH JOURNAL OF HAEMATOLOGY
journal article

Real-world Outcomes of Multiple Myeloma: Retrospective Analysis of the Czech Registry of Monoclonal Gammopathies
Roman Hájek, J. Jarkovsky, V. Maisnar, L. Pour, I. Spicka, J. Minarik, E. Gregora, P. Kessler, M. Sykora, H. Frankova, M. Campion, L. DeCosta, M. Treur, S. Gonzales-McQuire, W. Bouwmeester ... other authors
Year: 2018, Clinical Lymphoma Myeloma & Leukemia
journal article

The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets
Roman Hájek, Normann Steiner, Udo Müller, Sabina Sevcikova, Bojana Borjan, Karin Jöhrer, Georg Göbel, Andreas Pircher, Eberhard Gunsilius ... other authors
Year: 2018, PUBLIC LIBRARY SCIENCE
journal article

The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma
Roman Hájek, N. Steiner, S. Sevcikova, B. Borjan, G. Untergasser, G. Göbel, E. Gunsilius ... other authors
Year: 2018, Anticancer Research
journal article

The start of a new wave: Developments in proteasome inhibition in multiple myeloma
Roman Hájek, K. Yong, S. Gonzalez-McQuire, Z. Szabo, P. Schoen
Year: 2018, EUROPEAN JOURNAL OF HAEMATOLOGY
journal article

Treatment and outcome patterns in European patients with Waldenstrom's macroglobulinaemia: a large, observational, retrospective chart review
Roman Hájek, C. Buske, S. Sadullah, E. Kastritis, A. Tedeschi, R. García-Sanz, L. Bolkun, X. Leleu, W. Willenbacher, MC. Minnema, M. Cheng, E. Bilotti, T. Graef, MA. Dimopoulos ... other authors
Year: 2018, The Lancet Haematology
journal article

Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response
Roman Hájek, R. Mina, MT Petrucci, S. Spada, F. Patriarca, C. Cerrato, L. De Paoli, N. Pescosta, R. Ria, A. Malfitano, P. Musto, L. Baldini, T. Guglielmelli, B. Gamberi, D. Mannina, G. Benevolo, R. Zambello, AP Falcone, A. Palumbo, A. Nagler, V. Calafiore, A. Spencer, M. Boccadoro, P. Corradini, S. Bringhen ... other authors
Year: 2018, CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
journal article

Treatment Outcomes of Real Life Elderly Multiple Myeloma Patients: A Analysis from Registry of Monoclonal Gammopathies (RMG)
Roman Hájek
Year: 2018
abstract in proceedings

Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma
Tomáš Jelínek, Roman Hájek, B. Paiva
Year: 2018, Frontiers in Immunology
journal article

Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies
Jakub Radocha, Vladimír Maisnar, Luděk Pour, Ivan Špička, Jiři Minařík, Petr Pavlíček, Alexandra Jungová, Marta Krejčí, Tomáš Pika, Jan Straub, Lucie Brožová, Lukáš Stejskal, Adriana Heindorfer, Pavel Jindra, Petr Kessler, Peter Mikula, Michal Sýkora, Marek Wróbel, Jiří Jarkovský, Roman Hájek, Lenka Szeligová ... other authors
Year: 2018, Cancer Medicine
journal article

Venetoclax: A new wave in hematooncology
Jana Fečková Mihályová, Tomáš Jelínek, K. Growková, Matouš Hrdinka, Michal Šimíček, Roman Hájek ... other authors
Year: 2018, EXPERIMENTAL HEMATOLOGY
journal article

A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS)
Roman Hájek, T. Masszi, M. T. Petrucci, A. Palumbo, L. Rosinol, A. Nagler, K. L. Yong, A. Oriol, J. Minarik, M.A. Dimopoulos, V. Maisnar, D. Rossi, H. Kasparu, J. Van Droogenbroeck, D. B. Yehuda, I. Hardan, M. Jenner, M. Calbecka, M. Dávid, J. de la Rubia, J. Drach, Z. Gasztonyi, S. Górnik, X. Leleu, M. Munder, M. Offidani, N. Zojer, K. Rajangam, Y-L Chang, J. F. San-Miguel, H. Ludwig, L. Pour ... other authors
Year: 2017, LEUKEMIA
journal article

Activity of aldehyde dehydrogenase in B-cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors
P. Všianská, R. Bezděková, Fedor Kryukov, M. Almáši, L. Pour, M. Penka, Roman Hájek, L. Říhová ... other authors
Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY
journal article

Asymptomatic and treatment-requiring multiple myeloma - Data from the czech registry of monoclonal gammopathies
L. Brozova, J. Jarkovsky, L. Pour, J. Minarik, A. Jungova, E. Gregora, I. Spicka, V. Maisnar, Roman Hájek ... other authors
Year: 2017, Klinicka Onkologie
journal article

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: a pooled analysis
F. Gay, S. Oliva, M.T. Petrucci, V. Montefusco, C. Conticello, P. Musto, L. Catalano, A. Evangelista, S. Spada, P. Campbell, R. Ria, M. Salvini, M. Offidani, A.M. Carella, P. Omede, A.M. Liberati, R. Troia, A.M. Cafro, A. Malfitano, A.P. Falcone, T. Caravita, F. Patriarca, A. Nagler, A. Spencer, Roman Hájek, A. Palumbo, M. Boccadoro ... other authors
Year: 2017, LEUKEMIA
journal article

Bezdůvodný rozruch, nebo neuvěřitelný progres?
Roman Hájek
Year: 2017, Remedia
journal article

Biobanking strategy and sample preprocessing for integrative research in monoclonal gammopathies
Tereza Ševčíková, Kateřina Growková, Zuzana Kufová, Jana Filipová, P. Vrublová, Tomáš Jelínek, Zdeněk Kořístek, Fedor Kryukov, Elena Kryukova, Roman Hájek ... other authors
Year: 2017, JOURNAL OF CLINICAL PATHOLOGY
journal article

Biomarkers in immunoglobulin light chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors
Year: 2017, Klinicka Onkologie
journal article

Carfilzomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study ENDEAVOR (NCT01568866) according to age subgroup
H. Ludwig, M. A. Dimopoulos, P. Moreau, W-J Chng, H. Goldschmidt, Roman Hájek, T. Facon, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, A. Palumbo, H. H. Gillenwater, N. Mohamed, S. Aggarwal, S. Feng, D. Joshua ... other authors
Year: 2017, LEUKEMIA & LYMPHOMA
journal article

Carfilzomib, lenalidomide, and dexamethasone in patients with relapsed multiple myeloma categorised by age: secondary analysis from the phase 3 ASPIRE study
A. Meletios, A. K. Stewart, T. Masszi, I. Špička, A. Oriol, Roman Hájek, L. Rosinol, D. Siegel, G. G. Mihaylov, V. Goranova-Marinova, P. Rajnics, A. Suvorov, R. Niesvizky, A. Jakubowiak, J. San-Miguel, H. Ludwig, A. Palumbo, M. Obreja, S. Aggarwal, P. Moreau ... other authors
Year: 2017, BRITISH JOURNAL OF HAEMATOLOGY
journal article

Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial
M. A. Dimopoulos, H. Goldschmidt, R. Niesvizky, D. Joshua, W-J Chng, A. Oriol, R. Z. Orlowski, H. Ludwig, T. Facon, Roman Hájek, K. Weisel, V. Hungria, L. Minuk, S. Feng, A. Zahlten-Kumeli, A. S. Kimball, P. Moreau ... other authors
Year: 2017, LANCET ONCOLOGY
journal article

Carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR
W-J Chng, H. Goldschmidt, M. A. Dimopoulos, P. Moreau, D. Joshua, A. Palumbo, T. Facon, H. Ludwig, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, H. H. Gillenwater, N. Mohamed, S. Feng, S. Aggarwal, Roman Hájek ... other authors
Year: 2017, LEUKEMIA
journal article

Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment
M. A. Dimopoulos , A. K. Stewart, T. Masszi, I. Špička, A. Oriol, Roman Hájek, L. Rosinol, D. Siegel, G. G. Mihaylov, V. Goranova-Marinova, P. Rajnics, A. Suvorov, R. Niesvizky, A. Jakubowiak, J. San-Miguel, H. Ludwig, S. Ro, S. Aggarwal, P. Moreau, A. Palumbo ... other authors
Year: 2017, BLOOD CANCER JOURNAL
journal article

CRISPR in research and treatment of multiple myeloma
Michal Šimíček, Kateřina Growková, Roman Hájek
Year: 2017, Klinicka Onkologie
journal article

Current applications of multiparameter flow cytometry in plasma cell disorders
Tomáš Jelínek, R. Bezdekova, R. Zatopkova, L. Burgos, Michal Šimíček, Tereza Ševčíková, B. Paiva, Roman Hájek ... other authors
Year: 2017, BLOOD CANCER JOURNAL
journal article

Czech registry of monoclonal gammopathies - Technical solution, data collection and visualisation
L. Brozova, D. Schwarz, I. Snabl, J. Kalina, B. Pavlickova, M. Komenda, J. Jarkovsky, P. Nemec, D. Horinek, Z. Stefanikova, L. Pour, Roman Hájek, V. Maisnar ... other authors
Year: 2017, Klinicka Onkologie
journal article

Daratumumab - Naděje pro myelomové pacienty, výzva pro klinické laboratoře
Tomáš Jelínek, Martin Kořístka, Zuzana Čermáková, Roman Hájek
Year: 2017, Klinicka Onkologie
journal article

Diagnostic Tools of Waldenström's Macroglobulinemia - Best Possibilities for Non-invasive and Long-term Disease Monitoring
Kateřina Growková, Zuzana Kufová, Tereza Ševčíková, Jana Filipová, M. Kascak, Tomáš Jelínek, S. Grosicki, A. Barchnicka, L. Roziakova, M. Mistrik, M. Simicek, Roman Hájek ... other authors
Year: 2017, Klinická onkologie
journal article

DIFFERENCES IN PATIENT AND DISEASE CHARACTERISTICS OBSERVED AT INITIATION OF FIRST-LINE AND INITIATION OF SECOND-LINE TREATMENT IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA IN THE CZECH REPUBLIC
Roman Hájek
Year: 2017
abstract in proceedings

Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study
O. Sezer, M. Beksac, Roman Hájek, G. Sucak, S. Cagirgan, W. Linkesch, O. M. Akay, Z. Gülbas, H. Nahi, T. Plesner, J. A. Snowden, A. Timuragaoglu, T. Dechow, A. Lang, T. Tuglular, J. Drach, G. Armbrecht, A. Potamianou, C. Couturier, R. A. Olie, C. Feys, N. Allietta, E. Terpos ... other authors
Year: 2017, BRITISH JOURNAL OF HAEMATOLOGY
journal article

Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes
P. Hari, M.-V. Mateos, R. Abonour, S. Knop, W. Bensinger, H. Ludwig, K. Song, Roman Hájek, P. Moreau, D.S. Siegel, S. Feng, M. Obreja, S.K. Aggarwal, K. Iskander, H. Goldschmidt ... other authors
Year: 2017, LEUKEMIA
journal article

Epidemiology of multiple myeloma in the Czech Republic
D. Maluskova, I. Svobodova, M. Kucerova, L. Brozova, J. Muzik, J. Jarkovsky, Roman Hájek, V. Maisnar, L. Dusek ... other authors
Year: 2017, Klinicka Onkologie
journal article

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma
N. Steiner, B. Borjan, Roman Hájek, K. Jöhrer, G. Göbel, W. Willenbacher, J. Kern, E. Gunsilius, G. Untergasser ... other authors
Year: 2017, Oncotarget
journal article

High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma
N. Steiner, Roman Hájek, S. Sevcikova, B. Borjan, K. Jöhrer, G. Göbel, G. Untergasser, E. Gunsilius ... other authors
Year: 2017, PLOS ONE
journal article

Chromosome 1 amplification has similar prognostic value to del(17p13) and t(4;14)(p16;q32) in multiple myeloma patients: analysis of real-life data from the Polish Myeloma Study Group
N. Grzasko, Roman Hájek, M. Hus, S. Chocholska, M. Morawska, K. Giannopoulos, K. Czarnocki, A. Druzd-Sitek, B. Pienkowska-Grela, J. Rygier, L. Usnarska-Zubkiewicz, D. Dytfeld, T. Kubicki, A. Jurczyszyn, M. Korpysz, A. Dmoszynska ... other authors
Year: 2017, Leukemia and Lymphoma
journal article

IgM myeloma: A multicenter retrospective study of 134 patients
J. J. Castillo, A. Jurczyszyn, L. Brozova, E. Crusoe, J. Czepiel, J. Davila, A. Dispenzieri, M. Eveillard, M. A. Fiala, I. M. Ghobrial, A. Gozzetti, J. N. Gustine, Roman Hájek, V. Hungria, J. Jarkovsky, D. Jayabalan, J. P. Laubach, B. Lewicka, V. Maisnar, E. E. Manasanch, P. Moreau, E. A. Morgan, H. Nahi, R. Niesvizky, C. Paba-Prada, T. Pika, L. Pour, J. L. Reagan, P. G. Richardson, J. Shah, I. Spicka, R. Vij, A. Waszczuk-Gajda, M. A. Gertz ... other authors
Year: 2017, AMERICAN JOURNAL OF HEMATOLOGY
journal article

Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study
P. Moreau, D. Joshua, W-J Chng, A. Palumbo, H. Goldschmidt, Roman Hájek, T. Facon, H. Ludwig, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, H. H. Gillenwater, N. Mohamed, S. Aggarwal , S. Feng, M. A. Dimopoulos ... other authors
Year: 2017, LEUKEMIA
journal article

INITIAL PHASE 2 RESULTS OF IBRUTINIB COMBINED WITH BORTEZOMIB/DEXAMETHASONE IN PREVIOUSLY TREATED PATIENTS WITH MULTIPLE MYELOMA
Roman Hájek
Year: 2017
abstract in proceedings

Lymfomy z B-buněk marginální zóny
Juraj Ďuraš, Michal Kaščák, Roman Hájek
Year: 2017, Onkológia
journal article

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA ENROLLED IN THE EMN02/HO95 PHASE 3 TRIAL
Roman Hájek
Year: 2017
abstract in proceedings

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: RESULTS FROM THE EMN02/HO95 PHASE 3 TRIAL
Roman Hájek
Year: 2017
abstract in proceedings

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
P. Moreau, J. San Miguel, P. Sonneveld, M. V. Mateos, E. Zamagni, H. Avet-Loiseau, Roman Hájek, M. A. Dimopoulos, H. Ludwig, H. Einsele, S. Zweegman, T. Facon, M. Cavo, E. Terpos, H. Goldschmidt, M. Attal, C. Buske ... other authors
Year: 2017, ANNALS OF ONCOLOGY
journal article

Obinutuzumab v léčbě nemocných s chronickou lymfocytární leukémií a s folikulárním lymfomem
J. Zuchnická, J. F. Mihályová, Juraj Ďuraš, Roman Hájek
Year: 2017, Onkologická revue
journal article

Obtižne interpretovatelné nálezy elektroforéz a imunofixací u pacientu s mnohočetným myelomem po autologní transplantaci
Pavlína Kušnierová, David Zeman, Radka Šigutová, Zdeněk Švagera, Lenka Zahradová, Roman Hájek ... other authors
Year: 2017, Klinicka Biochemie a Metabolismus
journal article

PD-1/PD-L1 inhibitors in haematological malignancies
Tomáš Jelínek, J. Mihalyova, M. Kascak, J. Duras, Roman Hájek
Year: 2017, IMMUNOLOGY
journal article

PD-1/PD-L1 inhibitors in haematological malignancies: update 2017
Tomáš Jelínek, Roman Hájek, J. Mihalyova, M. Kascak, J. Duras
Year: 2017, Immunology
journal article

PD-1/PD-L1 inhibitors in multiple myeloma: The present and the future
Tomáš Jelínek, Roman Hájek
Year: 2017, ONCOIMMUNOLOGY
journal article

Pixantron v léčbě non-hodgkinských lymfomů
Juraj Ďuraš, Michal Kaščák, Milan Navrátil, Roman Hájek
Year: 2017, Onkologická revue
journal article

Proteasome inhibitors in AL amyloidosis: focus on mechanismof action and clinical activity
Tomáš Jelínek, Elena Kryukova, Zuzana Kufová, Fedor Kryukov, Roman Hájek
Year: 2017, Hematological Oncology
journal article

RISK STRATIFICATION ALGORITHM USING REAL-WORLD DATA FROM PATIENTS WITH RELAPSED AND/ OR REFRACTORY MULTIPLE MYELOMA: DESCRIPTION OF CLINICAL OUTCOME BY TREATMENT REGIMEN
Roman Hájek
Year: 2017
abstract in proceedings

Současný algoritmus léčby nemocných s mnohočetným myelomem - kam kráčí?
Roman Hájek, Tomáš Jelínek
Year: 2017, Acta medicinae
journal article

THE ORAL PROTEASOME INHIBITOR IXAZOMIB IN COMBINATION WITH MELPHALAN-PREDNISONE FOR PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: PHASE 1/2 DOSE-ESCALATION STUDY (NCT01335685)
Roman Hájek
Year: 2017
abstract in proceedings

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma
A. Mikulasova, Ch. P. Wardell, A. Murison, E. M. Boyle, G. H. Jackson, J. Smetana, Zuzana Kufová, L. Pour, V. Sandecka, M. Almasi, P. Vsianska, E. Gregora, P. Kuglik, Roman Hájek, F. E. Davies, G. J. Morgan, B. A. Walker ... other authors
Year: 2017, HAEMATOLOGICA
journal article

Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection
Kateřina Growková, Elena Kryukova, Zuzana Kufová, Jana Filipová, Tereza Ševčíková, L. Rihova, M. Kascak, Fedor Kryukov, Roman Hájek ... other authors
Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY
journal article

Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease
M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors
Year: 2017, Klinicka Onkologie
journal article

A Randomized Phase III Trial of Melphalan and Dexamethasone (MDex) Versus Bortezomib, Melphalan and Dexamethasone (BMDex) for Untreated Patients with AL Amyloidosis
Roman Hájek
Year: 2016
abstract in proceedings

A SUBSTUDY OF THE PHASE 3 ENDEAVOR STUDY: SERIAL ECHOCARDIOGRAPHIC ASSESSMENT OF PATIENTS WITH RELAPSED MULTIPLE MYELOMA (RMM) RECEIVING CARFILZOMIB PLUS DEXAMETHASONE OR BORTEZOMIB PLUS DEXAMETHASONE
Roman Hájek
Year: 2016
abstract in proceedings

AUTOLOGNÍ TRANSPLANTACE KMENOVÝCH BUNĚK U WALDENSTRÖMOVY MAKROGLOBULINEMIE
M. Kasčák, J. Duraš, M. Navrátil, Roman Hájek
Year: 2016, Transfuze a hematologie dnes
journal article

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study
M.A. Dimopoulos, P. Moreau, A. Palumbo, D. Joshua, L. Pour, Roman Hájek, T. Facon, H. Ludwig, A. Oriol, H. Goldschmidt, L. Rosiňol, J. Straub, A. Suvorov, C. Araujo, E. Rimashevskaya, T. Pika, G. Gaidano, K. Weisel, V. Goranova-Marinova, A. Schwarer, L. Minuk, T. Masszi, I. Karamanesht, M. Offidani, V. Hungria, A. Spencer, R. Z Orlowski, H. H Gillenwater, N. Mohamed, S. Feng, W.J. CHng ... other authors
Year: 2016, LANCET ONCOLOGY
journal article

CARFILZOMIB AND DEXAMETHASONE VERSUS BORTEZOMIB AND DEXAMETHASONE: SUBGROUP ANALYSIS OF THE PHASE 3 ENDEAVOR STUDY TO EVALUATE THE IMPACT OF PRIOR TREATMENT ON PATIENTS WITH RELAPSED MULTIPLE MYELOMA
Roman Hájek
Year: 2016
abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA: ANALYSIS OF THE PHASE 3 ENDEAVOR STUDY BY AGE SUBGROUP
Roman Hájek
Year: 2016
abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA: RESULTS OF THE PHASE 3 STUDY ENDEAVOR (NCT01568866)
Roman Hájek
Year: 2016
abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE: SUBGROUP ANALYSIS OF PATIENTS WITH RELAPSED MULTIPLE MYELOMA BY BASELINE CYTOGENETIC RISK STATUS (PHASE 3 ENDEAVOR STUDY)
Roman Hájek
Year: 2016
abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS SUBCUTANEOUS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA: SECONDARY ANALYSIS FROM THE PHASE 3 STUDY ENDEAVOR (NCT01568866)
Roman Hájek
Year: 2016
abstract in proceedings

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma
Herve Avet-Loiseau, Rafael Fonseca, David Siegel, Meletios A. Dimopoulus, Ivan Špička, Tomás Masszi, Roman Hájek, Laura Rosiňol, Vesselina Goranova-Marinova, Georgi Mihaylov, Vladimír Maisnar, Maria - Victoria Mateos, Michael Wang, Ruben Niesvizky, Albert Oriol, Andrzej Jakubowiak, Jiří Minarik, Antonio Palumbo, William Bensinger, Vishal Kukreti, Dina Ben-Yehuda, A. Keith Stewart, Mihaela Obreia, Philippe Moreau ... other authors
Year: 2016, Blood
journal article

CCR10/CCL27 crosstalk contributes to failure of proteasomeinhibitors in multiple myeloma
Shanmugapriya Thangavadievel, Claudia Zelle-Riser, Angelika Olivier, Benno Postert, Gerold Untergasser, Johann Kern, Andrea Brunner, Eberhard Gunsilius, Rainer Biedermann, Roman Hájek, Ludek Pour, Wolfgang Willenbacher, Richard Greil, Karin Johrer ... other authors
Year: 2016, ONCOTARGET
journal article

Centrosome amplification and clonal evolution in multiple myeloma: Short review
Elena Kryukova, Fedor Kryukov, Roman Hájek
Year: 2016, CRIT REV ONCOL HEMAT
journal article

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma
Fedor Kryukov, P. Nemec, L. Radova, Elena Kryukova, S. Okubote, J. Minarik, Z. Stefanikova, L. Pour, Roman Hájek ... other authors
Year: 2016, J TRANSL MED
journal article

CIRCULATING SERUM MIRNA PROFILE IN AL AMYLOIDOSIS
Elena Kryukova, Kateřina Growková, Jana Filipová, Fedor Kryukov, Roman Hájek
Year: 2016
abstract in proceedings

Clonal cytogenetics changes in progression of multiple myeloma to extramedullary relapse and plasmocellular leukemia: a case report
Jan Smetana, Petr Kuglik, Henrieta Greslikova, Renata Kupska, Pavel Nemec, Aneta Mikulasova, Iveta Valaskova, Jan Oppelt, Martina Almasi, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hájek ... other authors
Year: 2016, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
journal article

Cytogenetics in multiple myeloma patients progressing into extramedullary disease
Lenka Besse, Lenka Sedlarikova, Henrieta Greslíková, Renata Kupska, Martina Almasi, Miroslav Penka, Tomáš Jelínek, Luděk Pour, Zdeněk Adam, Petr Kuglik, Marta Krejci, Roman Hájek, Sabina Ševčíková ... other authors
Year: 2016, EUR J HAEMATOL
journal article

Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview
Fedor Kryukov, Elena Kryukova, Lucie Brožová, Zuzana Kufová, Jana Filipová, Kateřina Growková, Tereza Ševčíková, Jiří Jarkovský, Roman Hájek ... other authors
Year: 2016, GENE
journal article

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma
Robert Z. Orlowski, Arnon Narger, Pieter Sonneveld, Joan Bladé, Roman Hájek, Andrew Spencer, Tadeusz Robak, Anna Dmoszynska, Noemi Horvath, Ivan Spicka, Heather J. Sutherland, Alexander N. Suvorov, Liang Xiu, Andrew Cakana, Trilok Parekh, Jesus F. San-Miguel ... other authors
Year: 2016, CANCER
journal article

Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance
Aneta Mikulášová, J. Smetana, M. Wayhelova, H. Janyskova, V. Sandecka, Zuzana Kufová, M. Almasi, J. Jarkovsky, E. Gregora, P. Kessler, M. Wrobel, B.A. Walker, CH. P. Wardell, G.J. Morgan, Roman Hájek, P. Kuglik ... other authors
Year: 2016, EUR J HAEMATOL
journal article

Chronická lymfocytární leukemie -současné možnosti léčby
J. Zuchnická, J. Fečková Mihalyová, Roman Hájek
Year: 2016, Remedia
journal article

Ibrutinib v hematoonkologii
Jana Fečková Mihályová, Juraj Ďuraš, Jana Zuchnická, Michal Kaščák, Roman Hájek
Year: 2016, Klinická Farmakologie a Farmacie
journal article

Immunomodulatory drugs in AL amyloidosis
Tomáš Jelínek, Zuzana Kufová, Roman Hájek
Year: 2016, CRIT REV ONCOL HEMAT
journal article

Léčba starší nemocné s chronickou lymfocytární leukemií kombinací obinutuzumab a chlorambucil.
J. Zuchnická, J. Fečková Mihalyová, Roman Hájek
Year: 2016, Acta medicinae
journal article

Monoclonal antibodies - A new era in the treatment of multiple myeloma.
Tomáš Jelínek, Roman Hájek
Year: 2016, Blood reviews
journal article

Nové inovativní léky v léčbě mnohočetného myelomu.
Lenka Zahradová, Hana Plonková, Kristina Grácová, Roman Hájek
Year: 2016, Remedia
journal article

Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma
Valeria Magarotto, Sara Bringhen, Massimo Offidani, Giulia Benevolo, Francesca Patriarca, Roberto Mina, Antonietta Pia Falcone, Lorenzo De Paoli, Giuseppe Piatrantuono, Silvia Gentili, Caterina Musolino, Nicola Giuliani, Annalisa Bernardini, Concetta Conticello, Stefano Pulini, Giovannino Ciccone, Vladimír Maisnar, Marina Ruggeri, Renato Zambello, Tommasina Guglielmelli, Antonio Ledda, Anna Marina Liberati, Vittorio Montefusco, Roman Hájek, Mario Boccadoro, Antonio Palumbo ... other authors
Year: 2016, BLOOD
journal article

Waldenströmova makroglobulinémie v roce 2016: optimalizace imunochemoterapie s cílem minimalizace nežádoucích účinků
Michal Kaščák, Zuzana Kufová, Kateřina Growková, Roman Hájek
Year: 2016, Onkologia pre prax
journal article

Whole genome amplification effect on segmental copy-number changes and copy-number neutral loss of heterozygosity analysis by oligonucleotide-based array-comparative genomic hybridization in human myeloma cell line
Aneta Mikulášová, Jan Smetana, Markéta Wayhelová, Helena Janyskova, Samuel A Okubote, Roman Hájek, Petr Kuglik ... other authors
Year: 2016, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
journal article

Analysis of B-cell subpopulations in monoclonal gammopathies
Pavla Všianská, Lucie Říhová, Tamara Varmužová, Renata Suská, Fedor Kryukov, Aneta Mikulášová, Renata Kupská, Miroslav Penka, Luděk Pour, Zdeněk Adam, Roman Hájek ... other authors
Year: 2015, Clinical Lymphoma, Myeloma and Leukemia
journal article

Bortezomib, thalidomide and dexamethasone, with or without cyclophosphamide, for patients with previously untreated multiple myeloma: 5-year follow-up
Heinz Ludwig, Richard Greil, Tamas Masszi, Ivan Spicka, Ofer Shpilberg, Roman Hájek, Anna Dmoszynská, Bruno Paiva, María Belén Vidriales, Graca Esteves, Anne Marie Stoppa, Don Robinson, Jr., Shalini Chaturvedi, Ozlem Ataman, Christopher Enny, Huaibao Feng, Helgi van de Velde, Luisa Viterbo ... other authors
Year: 2015, BRIT J HAEMATOL
journal article

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma
A.Keith Stewart,M.B., S. Vincent Rajkumar, Meletios A. Dimopoulos, Tamas Masszi, Ivan Špička, Ph.D., Albert Oriol, Roman Hájek, Laura Rosiňol, Ph.D, David S. Siegel, Georgi G. Mihaylov, Vesselina Giranova-Marinová, Péter Rajnics, Aleksandr Suvorov, Ruben Niesvizky, Andrej J. Jakubowiak, Jesus F. San-Miguel, Heinz Ludwig, Michael Wang, Vladimír Maisnar, Jiří Minařík, Wiliam I. Bensinger, Mária-Victoria Mateos, Dina Ben-Yehuda, Vishal Kukreti, Naseem Zojwalla, Margaret E. Tonda, Xinqun Yang, Biao Xing, Philippe Moreau, Antonio Palumbo ... other authors
Year: 2015, NEW ENGL J MED
journal article

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma
Lenka Besse, Lenka Sedlaříková, Fedor Kryukov, Jana Nekvidová, Lenka Radová, Ondřej Slabý, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejčí, Zdeněk Adam, Luděk Pour, Sabina Ševčíková, Roman Hájek ... other authors
Year: 2015, PLOS ONE
journal article

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia
Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hájek, Sabina Sevcikova ... other authors
Year: 2015, American Journal of Hematology
journal article

Continuous Therapy Versus Fixed Duration of Therapy in Patients With Newly Diagnosed Multiple Myeloma
Antonio Palumbo, Francesca Gay, Federica Cavallo, Francesco Di Raimondo, Alessandra Larocca, Izhar Hardan, Arnon Nagler, Maria T. Petrucci, Roman Hájek, Sara Pezzatti, Michel Delforge, Francesca Patriarca, Francesca Donato, Chiara Cerrato, Chiara Nozzoli, Zhinuan Yu, Luana Boccadifuoco, Tommaso Caravita, Giulia Benevolo, Tommasina Guglielmelli, Donatella Vincelli, Christian Jacques, Meletios A. Dimopoulos, Giovannino Ciccone, Pellegrino Musto, Paolo Corradini, Michele Cavo, Mario Boccadoro ... other authors
Year: 2015, J CLIN ONCOL
journal article

European Myeloma Network. European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications
Evangelos Terpos, Martin Kleber, Monika Engelhardt, Sonja Zweegman, Francesca Gay, Efstathios Kastritis, Niels W.C.J. van de Donk, Benedetto Bruno, Orthan Sezer, Annemiek Broijl, Sara Bringhen, Meral Beksac, Alessandra Larocca, Roman Hájek, Pellegrino Musto, Hans Erik Johnsen, Fortunato Morabito, Heinz Ludwig, Michele Cavo, Hermann Einsele, Pieter Sonneveld, Meletion A. Dimopoulos, Antonio Palumbo ... other authors
Year: 2015, HAEMATOL-HEMATOL J
journal article

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data
Sabina Ševčíková, Helena Paszeková, Lenka Besse, Lenka Sedlariková, Veronika Kubaczková, Martina Almasi, Luděk Pour, Roman Hájek ... other authors
Year: 2015, BIOMEDICAL PAPERS-OLOMOUC
journal article

Flow cytometry in immunoglobulin light chain amyloidosis: Short review
Jana Filipová, Lucie Řihová, Pavla Vsianská, Zuzana Kufová, Elena Kryukova, Fedor Kryukov, Roman Hájek ... other authors
Year: 2015, LEUKEMIA RES
journal article

Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report
Antonio Palumbo, Sara Bringhen, Maria-Victoria Mateos, Alessandra Larocca, Thierry Facon, Shaji K. Kumar, Massimo Offidani, Philip McCarthy, Andrea Evangelista, Sagar Lonial, Sonja Zweegman, Pellegrino Musto, Evangelos Terpos, Andrew Belch, Roman Hájek, Heinz Ludwig, A. Keith Stewart, Philippe Moreau, Kenneth Anderson, Hermann Einsele, Brian G. M. Durie, Meletios A. Dimopoulos, Ola Landgren, Jesus F. San Miguel, Paul Richardson, Pieter Sonneveld, S. Vincent Rajkumar ... other authors
Year: 2015, BLOOD
journal article

Hereditární amyloidózy - etiologie, klinický obraz a léčba
Zuzana Kufová, T. Pika, T. Jelínek, Fedor Kryukov, Roman Hájek
Year: 2015, Transfuze a Hematologie Dnes
journal article

Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial
Francesca Gay, Stefania Oliva, Maria Teresa Petrucci, Concetta Conticello, Lucio Catalano, Paolo Corradini, Agostina Siniscalchi, Valeria Magarotto, Ludek Pour, Angelo Carella, Alessandra Malfitano, Daniela Petro, Andrea Evangelista, Stefano Spada, Norbert Pescosta, Paola Omede, Philip Campbell, Anna Marina Liberati, Massimo Offidani, Roberto Ria, Stefano Pulini, Francesca Patriarca, Roman Hájek, Andrew Spencer, Mario Boccadoro, Antonio Palumbo ... other authors
Year: 2015, LANCET ONCOL
journal article

MicroRNAs in urine are not biomarkers of multiple myeloma
Lenka Sedlaříková, Lenka Bešše, Soňa Novosadová, Veronika Kubaczková, Lenka Radová, Michal Staník, Marta Krejčí, Roman Hájek, Sabina Ševčíková ... other authors
Year: 2015, Journal of Negative Results in BioMedicine
journal article

Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma A Comparison with Real-Time PCR
Daniela Drandi, Lenka Kubiczkova-Besse, Simone Ferrero, Nadia Dani, Roberto Passera, Barbara Mantoan, Manuela Gambella, Luigia Monitillo, Elona Saraci, Paola Ghione, Elisa Genuardi, Daniela Barbero, Paola Omede, Davide Barberio, Roman Hájek, Umberto Vitolo, Antonio Palumbo, Sergio Cortelazzo, Mario Boccadoro, Giogio Inghirami, Marco Ladetto ... other authors
Year: 2015, J MOL DIAGN
journal article

Plasma cell leukemia: from biology to treatment
Tomáš Jelínek, Fedor Kryukov, Lucie Říhová, Roman Hájek
Year: 2015, EUR J HAEMATOL
journal article

Subcutaneous Bortezomib in Multiple Myeloma Patients Induces Similar Therapeutic Response Rates as Intravenous Application But It Does Not Reduce the Incidence of Peripheral Neuropathy
Jiří Minarik, Petr Pavlicek, Luděk Pour, Tomáš Pika, Vladimír Maisnar, Ivan Spicka, Jiří Jarkovský, Marta Krejci, Jaroslav Bacovský, Jakub Radocha, Jan Straub, Petr Kessler, Marek Wrobel, Lenka Walterova, Michal Sykora, Jarmila Obernauerova, Lucie Brozova, Evzen Gregora, Dagmar Adamova, Jaromir Gumulec, Zdenek Adam, Vladimir Scudla, Roman Hájek ... other authors
Year: 2015, PLOS ONE
journal article

Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
Lenka Kubiczkova, Fedor Kryukov, Ondrej Slaby, Elena Dementyeva, Jiri Jarkovsky, Jana Nekvindova, Lenka Radova, Henrieta Greslikova, Petr Kuglik, Eva Vetesnikova, Ludek Pour, Zdenek Adam, Sabina Sevcikova, Roman Hájek ... other authors
Year: 2014, Haematologica
journal article

Detekce hereditárních amyloidóz
Zuzana Kufová, Zuzana Ševčíková, Roman Hájek
Year: 2014, Klinická biochemie a metabolismus
journal article

European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma
Monika Engelhardt, Evangelos Terpos, Martina Kleber, Francesca Gay, Ralph Wäsch, Gareth Morgan, Michele Cavo, Niels van de Donk, Andreas Beilhack, Benedetto Bruno, Hans Erik Johnsen, Roman Hájek, Christoph Driessen, Heinz Ludwig, Meral Beksac, MArio Boccadoro, Christian Straka, Sara Brighen, Martin Gramatzki, Alessandra Larocca, Henk Lokhorst, Valeria Magarotto, Fortunato Morabito, Meletios A. Dimopoulos, Hermann Einsele, Pieter Sonneveld, Antonio Palumbo ... other authors
Year: 2014, Haematologica
journal article

European Perspective on Multiple Myeloma Treatment Strategies in 2014
Heinz Ludwig, Pieter Sonneveld, Faith Davies, Joan Blade, Mario Boccadoro, Michele Cavo, Gareth Morgan, Javier de la Rubia, Michel Delforge, Meletios Dimopoulos, Hermann Einsele, Thierry Facon, Hartmut Goldschmidt, Philippe Moreau, Hareth Nahi, Torben Plesner, Jesus San-Miguel, Roman Hájek, Pia Sondergeld, Antonio Palumbo ... other authors
Year: 2014, Oncologist
journal article

Factors that influence health-related quality of life in newly diagnosed patients with multiple myeloma aged >= 65 years treated with melphalan, prednisone and lenalidomide followed by lenalidomide maintenance: results of a randomized trial
Meletios A. Dimopoulos, Antonio Palumbo, Roman Hájek, Martin Kropff, Maria Teresa Petrucci, Philip Lewis, Stefanie Millar, Jingshan Zhang, Jay Mei, Michel Delforge ... other authors
Year: 2014, Leukemia & Lymphoma
journal article

Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience
Jan Smetana, Jan Frohlich, Romana Zaoralova, Vladimira Vallova, Henrieta Greslikova, Renata Kupska, Pavel Nemec, Aneta Mikulasova, Martina Almasi, Ludek Pour, Zdenek Adam, Viera Sandecka, Lenka Zahradová, Roman Hájek, Petr Kuglik ... other authors
Year: 2014, BIOMED RESEARCH INTERNATIONAL
journal article

Heterogenita a plasticita mnohočetného myelomu, aneb existuje skutečně myelomová kmenová buňka?
H. Šváchová, S. Okubote, Roman Hájek
Year: 2014
abstract in proceedings

International Myeloma Working Group Consensus Statement for the Management, Treatment, and Supportive Care of Patients With Myeloma Not Eligible for Standard Autologous Stem-Cell Transplantation
Antonio Palumbo, S. Vincent Rajkumar, Jesus F. San Miguel, Alessandra Larocca, Ruben Niesvizky, Gareth Morgan, Ola Landgren, Roman Hájek, Hermann Einsele, Kenneth C. Anderson, Meletios A. Dimopoulos, Paul G. Richardson, Michele Cavo, Andrew Spencer, A. Keith Stewart, Kazuyuki Shimizu, Sagar Lonial, Pieter Sonneveld, Brian G.M. Durie, Philippe Moreau, Robert Z. Orlowski ... other authors
Year: 2014, Journal of Clinical Oncology
journal article

International Myeloma Working Group recommendations for global myeloma care
H. Ludwig, JS Miguel, MA Dimopoulos, A Palumbo, R Garcia Sanz, R Powles, S Lentzsch, W Ming Chen, J Hou, A Jurczyszyn, K Romeril, Roman Hájek, E Terpos, K Shimizu, D Joshua, V Hungria, A Rodriguez Morales, D Ben-Yehuda, P Sondergeld, E Zamagni, B Durie ... other authors
Year: 2014, Leukemia
journal article

Management of Surgical Procedures in Patients with Inherited F VII Deficiency: Six Years of Experience
Radomira Hrdlickova, Sarka Blahutova, Roman Hájek, Zuzana Čermáková
Year: 2014, Journal of Blood Disorders & Transfusion
journal article

Nestin expression throughout multistep pathogenesis of multiple myeloma
Hana Svachova, Fedor Kryukov, Elena Kryukova, Sabina Sevcikova, Pavel Nemec, Henrieta Greslikova, Lucie Rihova, Lenka Kubiczkova, Roman Hájek ... other authors
Year: 2014, British Journal of Haematology
journal article

Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma
Lenka Kubiczkova, Ludek Pour, Lenka Sedlarikova, Roman Hájek, Sabina Sevcikova
Year: 2014, Journal of Cellular and Molecular Medicine
journal article

Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient data
Antonio Palumbo, Sara Bringhen, Shaji K. Kumar, Giulia Lupparelli, Saad Usmani, Anders Waage, Alessandra Larocca, Bronno van der Holt, Pellegrino Musto, Massimo Offidani, Maria T Petrucci, Andrea Evangelista, Sonja Zweegman, Ajay K Nooka, Andrew Spencer, Meletios A Dimopoulos, Roman Hájek, Michele Cavo, Paul Richardson, Sagar Lonial, Giovannino Ciccone, Mario Boccadoro, Kenneth Anderson, Bart Barlogie, Pieter Sonneveld, Philip L McCarthy ... other authors
Year: 2014, LANCET ONCOL
journal article

Soft-tissue extramedullary multiple myeloma prognosis is significantly worse in comparison to bone-related extramedullary relapse
Ludek Pour, Sabina Sevcikova, Henrieta Greslikova, Renata Kupska, Petra Majkova, Lenka Zahradova, Viera Sandecka, Zdenek Adam, Marta Krejci, Petr Kuglik, Roman Hájek ... other authors
Year: 2014, Haematologica
journal article

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network
Niels W. C. J. van de Donk, Antonio Palumbo, Hans Erik Johnsen, Monika Engelhardt, Francesca Gay, Henrik Gregersen, Roman Hájek, Martina Kleber, Heinz Ludwig, Gareth Morgan, Pellegrino Musto, Torben Plesner, Orhan Sezer, Evangelos Terpos, Anders Waage, Sonja Zweegman, Hermann Einsele, Pieter Sonneveld, Henk M. Lokhorst ... other authors
Year: 2014, Haematologica
journal article

The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma
Roman Hájek, David Siegel, Robert Z. Orlowski, Heinz Ludwig, Antonio Palumbo, Meletios Dimopoulos ... other authors
Year: 2014, Leukemia & Lymphoma
journal article

Využití imunomodulačních léků u amyloidózy
Roman Hájek, Tomáš Jelínek
Year: 2014, Mnohočetný myelom
journal article

Diagnostika a léčba systémové AL amyloidózy
Vlastimil Ščudla, Zdeněk Adam, Roman Hájek, Marta Krejčí, Tomáš Pika, Vladimír Maisnar, Patrik Flodr, Zuzana KUFOVÁ, Pavla Látalová, Anna Potáčová, Romana Ryšavá, Ivan Špička, Martin Tichý, Pavla Všianská ... other authors
Year: 2013, Transfuze a hematologie dnes
journal article

Mnohočetný myelom
Roman Hájek, Hana Plonková, Tomáš Jelínek
Year: 2013, Acta medicinae
journal article

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
Roman Hájek, Samuel A. Okubote, Hana Svachova
Year: 2013, BRIT J HAEMATOL
journal article

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group
C. Fernández de Larrea, R A. Kyle, B G M. Durie, H. Ludwig, S. Usmani, D H. Vesole, Roman Hájek, J F. San Miguel, O. Sezer, P. Sonneveld, S K. Kumar, A. Mahindra, R. Comenzo, A. Palumbo, A. Mazumber, K C. Anderson, P G. Richardson, A Z. Badros, J. Caers, M. Cavo, X. LeLeu, M A. Dimopoulos, C S. Chim, R. Schots, A. Noeul, D. Fantl, U-H. Mellqvist, O. Landgren, A. Chanan-Khan, P. Moreau, R. Fonseca, G. Merlini, J J. Lahuerta, J. Blade, R Z. Orlowski, J J. Shah ... other authors
Year: 2013, LEUKEMIA
journal article

Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma
Paul G. Richardson, Constantine S. Mitsiades, Jacob P. Laubach, Roman Hájek, Ivan Spicka, Meletios A. Dimopoulos, Philippe Moreau, David S. Siegel, Sundar Jagannath, Kenneth C. Anderson ... other authors
Year: 2013, LEUKEMIA RES
journal article

Thalidomid v léčbě mnohočetného myelomu se zaměřením na kombinaci s bortezomibem
Roman Hájek, Jaromír Gumulec
Year: 2013, Klinická onkologie
journal article

Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study
Meletios Dimopoulos, David S Siegel, Sagar Lonial, Junyuan Qi, Roman Hájek, Thierry Facon, Laura Rosinol, Catherine Williams, Hilary Blacklock, Hartmut Goldschmidt, Vania Hungia, Andrew Spencer, Antonio Palumbo, Thorsten Graef, Joseph E Eid, Jennifer Houp, Linda Sun, Scott Vuocolo, Kenneth C Anderson ... other authors
Year: 2013, LANCET ONCOL
journal article

Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)
Roman Hájek, Richard Bryce, Sunhee Ro, Barbara Klencke, Heinz Ludwig
Year: 2012, BMC CANCER
journal article

Kombinovaná léčba nemocných s mnohočetným myelomem - lenalidomid
Roman Hájek, Hana Plonková
Year: 2012, Acta Medicinae
journal article

Lenalidomide, melphalan, and prednisone followed by lenalidomide maintenance improves health-related quality of life in newly diagnosed multiple myeloma patients aged 65 years or older: results of a randomized phase III trial
M. A. Dimopoulos, M. Delforge, Roman Hájek, M. Kropff, MT Petrucci, P. Lewis, A. Nixon, J. Zhang, J. Mei, A. Palumbo ... other authors
Year: 2012, Haematologica
journal article

Lenalidomid v dlouhodobé strategii léčby mnohočetného myelomu
Hana Plonková, Tomáš Jelínek, Lenka Zahradová, Roman Hájek
Year: , Mnohočetný myelom
journal article

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AuthorTitleType of thesisYear
Jelínek TomášModern immunotherapy in the treatment of multiple myeloma and acute myeloid leukemiaDoctoral thesis 2020 
Filipová JanaSelection and separation of cells using flow cytometry with focusing on rare monoclonal gammapathiesMaster's thesis 2015 
Kočí RenátaOptions of inhibition of the mitotic spindle by modern medicaments in the blood cancer issueBachelor's thesis 2016 


Molecular, cellular and clinical approach to healthy ageing
Main solverprof. MUDr. Roman Hájek, CSc.
Period9/2018 - 6/2023
ProviderOperační program Výzkum, vývoj a vzdělávání (OP VVV)
Statesolved
WE ARE "OSTRAVSKÁ" = THE MODERN, INSPIRATIONAL AND ATTRACTIVE PLACE FOR QUALITY STUDY
Main solverprof. MUDr. Roman Hájek, CSc.
Period5/2017 - 12/2022
ProviderRektorát, Operační program Výzkum, vývoj a vzdělávání (OP VVV)
Statesolved
New Directions of Biomedical Research in the Ostrava Region
Main solverprof. MUDr. Roman Hájek, CSc.
Period5/2019 - 12/2022
ProviderDěkanát LF, Operační program Výzkum, vývoj a vzdělávání (OP VVV)
Statesolved
University for Region
Main solverprof. MUDr. Roman Hájek, CSc.
Period1/2019 - 12/2022
ProviderRektorát, Operační program Výzkum, vývoj a vzdělávání (OP VVV)
Statesolved
Aberrant plasma cells clonal diversification in immunoglobulin light chain amyloidosis
Main solverprof. MUDr. Roman Hájek, CSc.
Period5/2015 - 12/2019
ProviderIGA MZd
Statefinished
PRO-Ost
Main solverprof. MUDr. Roman Hájek, CSc.
Period1/2017 - 10/2019
ProviderCentrum excelence IT4Innovations, divize, Děkanát FSS, Děkanát FU, Děkanát LF, Děkanát PdF, Děkanát PřF, Rektorát, Univerzitní knihovna, Operační program Výzkum, vývoj a vzdělávání (OP VVV)
Statein sustainability
Bone Marrow Microenvironment in Multiple Myeloma: Application of 2D and 3D in vitro models using patient's specific IPSCs derived Mesenchymal Stem cells
Main solverprof. MUDr. Roman Hájek, CSc.
Period8/2016 - 12/2017
ProviderKatedra interních oborů, Projekty podporované z rozpočtu měst krajských úřadů
Statefinished
Podpora přípravy klíčových projektů OU v operačních programech EU pro nové programovací období
Main solverprof. MUDr. Roman Hájek, CSc.
Period1/2015 - 12/2015
ProviderRozvojové programy MŠMT
Statefinished
Zahájení dlouhodobého výzkumu u monoklonálních gamapatií
Main solverprof. MUDr. Roman Hájek, CSc.
Period12/2014 - 12/2015
ProviderLékařská fakulta, Projekty podporované z rozpočtu měst krajských úřadů
Statefinished
Zavedení metody sekvenování nové generace (next generation sequencing) v rámci screeningu hereditárních amyloidóz v České republice/ Dotační titul 2
Main solverprof. MUDr. Roman Hájek, CSc.
Period9/2014 - 8/2015
ProviderLékařská fakulta, Přírodovědecká fakulta, Projekty podporované z rozpočtu měst krajských úřadů
Statefinished
Dynamics of microRNA and cellfree DNA profiles during multiple myeloma progression
Main solverprof. MUDr. Roman Hájek, CSc.
Period1/2014 - 12/2014
ProviderOstatní projekty ze zahr. prostředků
Statefinished
Zavedení a využití metody separace jednotlivých buněk pomocí imunofluorescenčních metod a následné aplikace v hematoonkologii
Main solverprof. MUDr. Roman Hájek, CSc.
Period10/2013 - 12/2014
ProviderLékařská fakulta, Projekty podporované z rozpočtu měst krajských úřadů
Statefinished
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