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Internal Grant Competition DGC
START-UP grant

Changes in body composition and biomechanics gait in patients after bariatric and metabolic surgery.
Project IdSGS14/PdF/2023
Main solverMgr. Veronika Horká, DiS.
Period1/2023 - 12/2023
ProviderSpecifický VŠ výzkum
AnotationOver the past two decades, obesity has become a serious global health problem. In Central and Eastern European countries, the prevalence of obesity is at the forefront of all epidemiological studies [1,2]. Since the late 1990s, surgical treatment (BMS) has emerged as the most effective treatment for obesity [3]. In contrast to conservative treatment, which fails in more than 80% of patients, metabolic surgery leads to long-term success in more than 80% of patients [4]. Patients with obesity are also at risk for comorbidities such as type II diabetes, hepatic steatosis, hypertension, sarcopenic obesity, and others. The combination of low muscle mass and low strength with increased fat mass can further exacerbate metabolic disorders and physical disability with a synergistic effect [5]. Joint guidelines issued by the American Society for Metabolic and Bariatric Surgery, the Obesity Society, and the American Association of Clinical Endocrinologists recommend that patients follow a healthy lifestyle after surgery that includes exercise for at least 30 minutes per day [6]. BMS leads to significant changes in body composition. Significant fat loss is also followed by unintended loss of muscle mass. The combination of low muscle mass and strength with increased fat mass infiltration, known as sarcopenic obesity, may synergistically promote further exacerbation of metabolic disorders and physical disability. In addition, sarcopenia in obese subjects is associated with a higher risk of hypertension, arterial stiffness, dyslipidaemia, insulin resistance, knee arthritis and osteoporosis, resulting in an increased risk of falls and fractures and difficulties with physical function. The lack of physical activity typical of these patients has been found to contribute to this effect [7]. Therefore, further research is needed to elucidate the pathophysiological mechanism responsible for sarcopenic obesity as well as the effect of exercise on muscle tissue in post-BMS patients [8].