Projects & Grants

Internal Grant Competition DGC

Vascular changes on laryngeal and hypopharyngeal lesions - is the Type IV vascularisation according to Ni benign or malignant?
Project IdSGS22/LF/2022
Main solverMUDr. Lucia Staníková, Ph.D.
Period1/2022 - 12/2022
ProviderSpecifický VŠ výzkum
AnotationEarly diagnosis of cancer seems to be challenge for each field of medicine to improve diagnostic methods. Impact of enhanced endoscopy increases in the last years and that is the reason of improved detection of carcinomas in ENT region, especially in larynx. NBI (narrow band imaging) or IMAGE1-S (postprocessing filtration of the image using Storz Professional Image Enhancement System) techniques in combination with HD TV should visualized vascular changes in the epithelium. Based on the appearance of intraepithielial papillary capillary loops (IPCLs) we can evaluate character of epithelial changes and perform an ?optical? biopsy. These methods are considered to be gold standard of laryngeal examination. Epithelial vascular changes could be the first sign of malign transformation of the laryngeal lesion. Correct interpretation and evaluation of these IPCLs seem to be essential for early diagnosis of precancerous changes or carcinoma, respectively. Nowadays exists more different classifications of microvascular changes (Ni et al. 2011, Puxeddu et al. 2015, Arens et al. 2016, Ni et al. 2019). Many scientific articles discuss sensitivity and specificity these sophisticated endoscopic method in diagnosis of dysplastic or cancer lesions. Evaluation of clinically and endoscopically evident benign or malignant lesions is not complicated. IPCL Type IV according to Ni et al. (2011) regards a ?grey? area of interpretation of vascular changes. Ni et al. considered these IPCLs as benign type of vascular loops. On the other hand classification recommended European Laryngological Society and published by Arens et al. (2016) described dots-like changes like perpendicular vascularisation with malignant potential. Non-uniformity of classifications of intraepithelial vascular changes get worse prediction of malignant transformation of lesions in clinical praxis.