Projects & Grants

Internal Grant Competition DGC

Effect of long-term exposure to air pollution and lung function on cardiopulmonary mortality in aging women
Project IdSGS09/LF/2020
Main solverMgr. Andrea Dalecká
Period1/2020 - 12/2020
ProviderSpecifický VŠ výzkum
AnotationAccording to the World Health Organization (WHO), air pollution has been identified as a global health threat, which extensively contributes to premature deaths caused by severe non communicable diseases, such as ischemic heart disease, stroke, chronic obstructive lung disease and lung cancer. Based on recent results, ambient particulate matter caused for about 85 million disability-adjusted life years (DALYs). Only in Europe, Ambient air pollution contributes to 790 000 premature deaths per every year. A number of epidemiological studies have been searching for a relationship between the exposure to ambient air pollution and the incidence of a number of adverse effects originating as a consequence of this environmental risk factor. Most cohort studies published today dealing with the study of effect of long-term exposure to ambient air pollution come from North America or East Asia. The results of a number of similar studies cannot be fully applied upon the conditions of European countries, as there exist a number of variables, which are specific for the respective areas. Supporting long-term research on new or existing cohorts is a prerequisite for complementing a number of still poorly described relationships between air pollution exposures and cardiopulmonary mortality. The assumption of this study is using data from the SALIA (Study of the effect of Air pollution on Lung function, Inflammation and Aging). This cohort was established in 1986 and contains 4874 participants in total from nine different study areas in a highly and lowly industrialized districts of Germany. The aim of this study if estimating of survival analysis of cardiopulmonary mortality with focusing on the reduced lung functions and long-term exposures to ambient air pollution. Moreover, the investigation of covariates, especially socio-economics and lifestyle ones will be carried out.