Projects & Grants

Internal Grant Competition DGC

Pilot study: Extension of diagnostic possibilities of a new type of ventricular dyssynchrony detection
Project IdSGS/06/LF/2020-2021
Main solverMUDr. Bc. Eva Závodná, Ph.D.
Period1/2020 - 12/2021
ProviderSpecifický VŠ výzkum
AnotationVentricular dyssynchrony means that there are significant time delays between the right and left ventricles or within particular segments mainly of the left ventricle. This disturbation of cardiac ventricular activation synchronicity results in impaired systolic heart function leading to heart failure. The current possibilities of cardiac dyssynchrony evaluation by echocardiography allows only a very clumsy and rough estimation of time delays. Recently a new invention of the Institute of Scientific Instruments of the Academy of Sciences of the Czech Republic appeared, whose unique approach to electrical activity of the heart detection and processing allows relatively rapid and easy detection of even fighn deviations of cardiac ventricular activation time shifts (device VDI Monitor - Ventricular Dyssynchrony Imaging Monitor). This methodology was developed to measure the time delay between ventricles and to determine the conduction disturbances in the heart. At present, this method is mainly applied to the detection of dyssynchrony, electrode placement optimization and cardiac resynchronization therapy parameter settings. Due to the novelty of this device, new diagnostic areas can be found. Therefore, the aim of this pilot study will be to identify appropriate diagnoses in which ventricular dyssynchrony can be predicted due to the pathophysiological mechanism of disease development but cannot be easily detected by current methods. One of the possibilities is the examination of patients after myocardial infarction, in whom the detection of development of cardiac dyssynchrony could predict the risk of transition to heart failure. Also, the records of patients with heart failure other than post-infarction, cardiomyopathy or various arrhythmias would not be of interest. Another interesting area is the detection of cardiotoxicity after antitumor treatment, as antitumor chemotherapeutics may interfere with cardiomyocyte function by their mechanism of action.