Projects & Grants

Internal Grant Competition DGC
START-UP grant

4D strain echocardiographic analysis
Project IdSGS01/LF/2020
Main solverIng. Martina Polochová, DiS., MBA, LL.M.
Period1/2020 - 12/2020
ProviderSpecifický VŠ výzkum
AnotationDeformation imaging has been shown to add incremental information in many clinical settings and disease states, especially regarding regional wall motion abnormalities. 2D speckle tracking is the most preferred method nowadays b/c good spatial and temporal resolution and angle independency in comparison with tissue doppler derived techniques1. Global longitudinal strain seems to be most robust and reproducible parameter of global myocardial wall motion abnormalities and the only one officially recommended for the LV function analysis2. 2D strain analysis is derived only from 3 planes (apical 4C, apical 2C and APLAX) in order to capture all the 17-segments. On the other hand, 4D strain imaging calculates the whole strain analysis from 4D apical volumetric analysis with the advantage of assessing 3D instead of 3 2D planes, while decreasing slightly the temporal resolution. 4D Strain has the potential to become the reference method to assess myocardial function and detect early, subclinical myocardial involvement in many heart diseases as well as to quantify regional myocardial function in ischaemic heart disease. 4D strain is at a time not recommended for clinical use outside clinical trials, as well as the assessment of right ventricular function (AutoRVQ), RV free wall strain analysis or even left atrial strain analysis. The main objective of this project is to compare the regular 2D speckle tracking method (AFI, as a gold standard) to 4D strain analysis (AutoLVQ) in different heart diseases, specifically in patients with pacemaker or patient with cardiac resynchronization therapy.