Projects & Grants

Internal Grant Competition DGC
START-UP grant

The preeminence of magnetic resonance imaging in rectal cancer
Project IdSGS04/LF/2018
Main solverMUDr. Daniel Toman, Ph.D.
Period1/2018 - 12/2018
ProviderSpecifický VŠ výzkum
AnotationMagnetic resonance imaging (MRI) in rectal cancer was first investigated in 1999 and has become almost mandatory in planning rectal cancer treatment. MRI has a high accuracy in predicting circumferential resection margin involvement and is used to plan neoadjuvant therapy. Reassessment of MRI scans after preoperative therapy has implications for surgical planning, the timing of surgery, sphincter preservation, deferral of surgery for good responders, and development of further preoperative treatments for radiologically identified poor responders. MR is used to stage low rectal tumors and plan plane of surgery (standard surgery, abdominoperineal resection with permanent colostomy) Surgical treatment is currently the only the only form of treatment that currently offers a chance of long-term survival. Radical surgical removal of the tumour is however accompanied by other therapeutic modalities, including chemotherapy, radiotherapy and, in cases of metastases, targeted biological therapy as well. The surgical therapy itself has undergone major progress in recent decades. The number of oncologically radical procedures has grown, the number of patients affected by a permanent colostomy has decreased and by introducing the concept mesorectal excision, the number of local relapses significantly decreased.