Projects & Grants

Internal Grant Competition DGC
START-UP grant

Evolution of parasitism in Trypanosomatidae
Project IdSGS27/PřF/2015
Main solverprof. MSc. Vjačeslav Jurčenko, Ph.D.
Period1/2015 - 12/2015
ProviderSpecifický VŠ výzkum
AnotationTrypanosomatids are widespread parasites causing numerous diseases of vertebrates, including humans. The best known members are Trypanosoma (responsible for African sleeping sickness and Chagas disease) and Leishmania species (causative agents of leishmaniases which seriously affect millions of people in the tropics and sub-tropics). All these parasites are dixenous, meaning they have two different hosts - invertebrates and vertebrates - in their life cycle. Also included in the family Trypanosomatidae are numerous monoxenous (only one invertebrate host) species of the genera Leptomonas, Crithidia, Herpetomonas, Sergeia, Blastocrithidia, Kentomonas, Blechomonas, etc. The aim of this project is to investigate origin of parasitism in Trypanosomatidae as is, and specific diffierences between the monoxenous and dixenous relatives using genetic, molecular biology, and biochemical tols developed in my laboratory.